Copper-tyrosyl radical enzymes |
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Authors: | Rogers Melanie S Dooley David M |
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Institution: | Department of Chemistry and Biochemistry, Gaines Hall, Montana State University, Bozeman, MT 59717, USA. mrogers@copper.chemistry.montana.edu |
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Abstract: | Advances have been made since 2000 that contribute to our understanding of the biogenesis, structure and mechanism of copper-containing tyrosyl radical enzymes. Efforts to detail the biogenesis of galactose oxidase have produced the structure of the precursor enzyme, which provides a framework for emerging mechanistic studies. The role of the tyrosyl radical of cytochrome c oxidase is being defined in studies that aim to understand the His-Tyr crosslink, the location of the radical and, by direct attempts, to provide evidence for the radical during turnover. |
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