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The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class |
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| Authors: | Sciotti Richard J Pliushchev Marina Wiedeman Paul E Balli Darlene Flamm Robert Nilius Angela M Marsh Kennan Stolarik DeAnne Jolly Robert Ulrich Roger Djuric Stevan W |
| Affiliation: | Abbott Laboratories, Infectious Disease Research, Department 47N, Abbott Park, IL 60064, USA. richard.sciotti@pfizer.com |
| Abstract: | A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid. |
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