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Increased activation of antigen-primed or memory B cells by bacterial lipopolysaccharide |
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| Authors: | M B Fauntleroy J A Rudbach B Prescott P J Baker |
| Affiliation: | 1. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, United States of America;2. Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States of America;1. Thayer School of Engineering, Dartmouth College, Hanover, NH, USA;2. Department of Microbiology and Immunology, Geisel School of Medicine, Hanover, NH, USA;3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA |
| Abstract: | Treatment with bacterial lipopolysaccharide elicits the appearance of greater numbers of background antigen-specific plaque-forming cells (PFC) in the spleens of mice previously exposed or primed to subimmunogenic amounts of various non-cross-reacting antigens so as to generate detectable immunological memory. These findings suggest that treatment with lipopolysaccharide results in the activation of increased numbers of antigen-primed or memory B cells in mice previously exposed to antigen. |
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