PGE2 is a more potent vasodilator of the lamb ductus arteriosus than is either PGI2 or 6 keto PGFα |
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| Authors: | Ronald I. Clyman, Fran oise Mauray, Christine Roman,Abraham M. Rudolph |
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| Affiliation: | 1. The Cardiovascular Research Institute and the Departments of Pediatrics, Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143, USA;2. Department of Pediatrics, Mt. Zion Medical Center, San Francisco, California 94115, USA |
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| Abstract: | It has been shown in vitro that the lamb ductus arteriosus forms prostaglandins PGE2, PGF2α, 6 keto PGF1α (and its unstable precursor PGI2). In this study the relative potencies of these endogenous prostaglandins were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated PO2 and indomethacin. All the prostaglandins (except PGF2α) relaxed the vessel. This is consistent with the hypothesis that endogenous prostaglandins inhibit the tendency of the vessel to contract in response to oxygen. Only PGE2, however, relaxed the vessel at concentrations below 10−8M. PGI2 and 6 keto PGF1α had approximately 0.001 and 0.0001 times the activity of PGE2. Although PGE2 has been observed to be a minor product of prostaglandin production in the lamb ductus arteriosus, the tissue's marked sensitivity to PGE2 might make it the most significant prostaglandin in regulating the patency of the vessel. |
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