A paternal balanced translocation [t(7;22)(q32;q13.3)] leading to reciprocal unbalanced karyotypes in two consecutive pregnancies |
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| Authors: | J L Zackowski L J Raffel L D McDaniel S Schwartz |
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| Institution: | Division of Human Genetics, University of Maryland School of Medicine, Baltimore 21201. |
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| Abstract: | A family is reported in which a man with a balanced reciprocal translocation 46,XY,t(7;22)(q32;q13.3)] fathered a daughter who was trisomic for the region 7q32----7qter and monosomic for 22q13.3----22qter, and a male fetus who was monosomic for 7q32----qter and trisomic for 22q13.3----22qter. The meiotic segregation of this translocation, as well as the phenotypes of the unbalanced offspring, are discussed. |
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