Graft-versus-host reactivity of human lymphoid cells from established cell lines |
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| Authors: | J Gordon K Taguchi R I Constantine L D MacLean |
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| Affiliation: | 1. Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt;2. Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo, Egypt |
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| Abstract: | Cells from three out of five established human lymphoid cell lines gave reactions when injected under the kidney capsule of rats pretreated with cyclophosphamide. These reactions were characterized by mononuclear cell infiltration and destruction of the kidney cortex. No reactions were obtained when the cells were incubated with anti-human lymphocyte serum or were treated with mitomycin. Reactions could not be elicited in irradiated or ALS-treated recipients. The reactions obtained were indistinguishable from the graft-versus-host reactions given by fresh human buffy coat leukocytes. |
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