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Squaric acid derivatives as VLA-4 integrin antagonists |
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| Authors: | Porter John R Archibald Sarah C Childs Kirstie Critchley David Head John C Linsley Janeen M Parton Ted A H Robinson Martyn K Shock Anthony Taylor Richard J Warrellow Graham J Alexander Rikki P Langham Barry |
| Affiliation: | Celltech R&D Ltd, 216 Bath Road, Slough SL1 4EN, UK. john.porter@celltechgroup.com |
| Abstract: | SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series of VLA-4 integrin antagonists are described. |
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