Synthesis and cytotoxic activity of estrogen alpha-methylene-delta-lactones |
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| Authors: | L S Chagonda P M Lockey B A Marples J R Traynor |
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| Institution: | Department of Chemistry, The University of Technology, Loughborough, Leicestershire, U.K. |
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| Abstract: | Several estrogen derivatives containing the alpha-methylene-delta-lactone group as part of the D-ring were prepared as anti-tumor agents. The compounds were highly toxic towards HeLa S3 cells grown in culture. |
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| Keywords: | To whom correspondence should be addressed |
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