| 树鼩作为丙型肝炎动物模型的HCV受体研究进展 |
| |
| 引用本文： | 李尧,代解杰,孙晓梅,夏雪山.树鼩作为丙型肝炎动物模型的HCV受体研究进展[J].动物学研究,2011,32(1):97-103. |
| |
| 作者姓名： | 李尧 代解杰 孙晓梅 夏雪山 |
| |
| 作者单位： | 李尧,夏雪山,LI Yao,XIA Xue-Shan(昆明理工大学生命科学与技术学院,云南,昆明,650224);代解杰,孙晓梅,DAI Jie-Jie,SUN Xiao-Mei(中国医学科学院冲国协和医科大学,昆明医学生物研究所,云南,昆明,650118) |
| |
| 基金项目： | 国家重点基础研究研究计划项目，国家十一五科技支撑计划项目 |
| |
| 摘 要： | 丙型肝炎病毒(hepatitis C virus,HCV)全球流行、危害严重,合适的小动物模型的缺乏严重阻碍了药物和疫苗的研发。该文介绍丙型肝炎危害与病毒复制特点,以HCV入胞受体为重点,通过比较现有丙型肝炎动物模型,从分子水平探讨树鼩作为丙型肝炎动物模型的可能性。
|
| 关 键 词： | 丙型肝炎 树鼩 动物模型 受体 |
| 收稿时间： | 2010-12-03 |
| 修稿时间： | 2011-01-20 |
Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model |
| |
| LI Yao,DAI Jie-Jie,SUN Xiao-Mei,XIA Xue-Shan.Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model[J].Zoological Research,2011,32(1):97-103. |
| |
| Authors: | LI Yao DAI Jie-Jie SUN Xiao-Mei XIA Xue-Shan |
| |
| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming Yunnan 650224, China; 2. Institute of Medical Biology, Chinese Academy of Medical Science &; Peking Union Medical College, Kunming Yunnan 650018, China |
| |
| Abstract: | Hepatitis C virus is a prevalent and globally distributed human pathogen that seriously harmful to public health. However, the development of therapy and vaccine was impeded by the lack of suit small animal models. Herein, we introduce the characters of HCV replication. Taken the HCV cellular receptors as the viewpoint, the potentiality of tupaia as hepatitis C animal model is discussed at the molecular level by comparing of present animal model. |
| |
| Keywords: | Hepatitis C Tupaia Animal model Receptor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《动物学研究》浏览原始摘要信息 |
| 点击此处可从《动物学研究》下载免费的PDF全文 |
|
