| 调控精子获能的相关因素 |
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| 引用本文： | 周勇,曾海涛. 调控精子获能的相关因素[J]. 生命科学研究, 2012, 16(4): 368-371 |
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| 作者姓名： | 周勇 曾海涛 |
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| 作者单位： | 中南大学生物科学与技术学院分子生物学研究中心,中国湖南长沙,410078 |
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| 摘 要： | 获能是精子发生顶体反应以及与卵子结合之前所必需的生理过程,目前精子获能的机制得到初步阐明,获能伴随着质膜重组,离子通道的调节,胆固醇的流失以及许多蛋白磷酸化状态的改变.获能同时受到内在和外在因子的调节,其中胆固醇、HCO3-、Ca2+以及蛋白磷酸化在精子获能过程中发挥着重要作用.
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| 关 键 词： | 获能 胆固醇 HCO3- Ca2+ 蛋白磷酸化 |
Factors Regulating Sperm Capacitation |
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| ZHOU Yong , ZENG Hai-tao. Factors Regulating Sperm Capacitation[J]. Life Science Research, 2012, 16(4): 368-371 |
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| Authors: | ZHOU Yong ZENG Hai-tao |
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| Affiliation: | (Molecular Biology Research Center,School of Biological Science and Technology,Central South University,Changsha 410078,Hunan,China) |
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| Abstract: | Capacitation is an important physiological pre-requisite that enables sperm undergo acrosome re-action and fertilize the egg.At present,the mechanism of sperm capacitation is preliminary elucidated.The known changes associated with sperm capacitation include: plasma membrane reorganization,ion permeabili-ty regulation,cholesterol efflux and changes in the phosphorylation state of many proteins.Capacitation is regulated by both intrinsic and extrinsic factors,the effect of cholesterol,HCO3-,Ca2+and protein phosphory-lation play an important role during capacitation. |
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| Keywords: | capacitation cholesterol HCO3- Ca2+ protein phosphorylation |
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