Studies with a human plasma-derived immunosuppressive,anti-lymphoma factor |
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| Authors: | Jeffrey L Farmer Morton D Prager |
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| Institution: | (1) Department of Surgery, University of Texas Health Science Center, 75235 Dallas, TX, USA;(2) Department of Biochemistry, University of Texas Health Science Center, 75235 Dallas, TX, USA;(3) Department of Graduate Program in Immunology, University of Texas Health Science Center, 75235 Dallas, TX, USA;(4) Present address: Imreg Inc., Suite 1400, 144 Elk Place, 70112 New Orleans, LA, USA |
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| Abstract: | Summary A low-molecular-weight (1,400) factor isolated from a human plasma  -globulin concentrate by acid-salt dissociation and ultrafiltration inhibits proliferation of mitogen-stimulated T cells and L1210 leukemia cells. The factor (UM05R) inhibits DNA, RNA, and protein synthesis in sensitive cells, acts in G1 of the cell cycle, and appears to suppress mitogen-responsive T cells without an accessory cell requirement. UM05R activity is enhanced by known cAMP-elevating agents and by sulfhydryl compounds. The results of the present study are consistent with the hypothesis that the plasma-derived agent inhibits lympho-proliferation as a result of elevation of intracellular cAMP. |
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