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Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue |
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| Authors: | Tarttelin Emma E Bellingham James Hankins Mark W Foster Russell G Lucas Robert J |
| Affiliation: | a Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, St. Dunstan’s Road, London W6 8RP, UK b School of Biological Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK c Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, St. Dunstan’s Road, London W6 8RP, UK |
| Abstract: | We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. |
| Keywords: | Opsin Photopigment Photoisomerase Neural expression |
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