我国疾病动物模型的研究现状和展望

由于医学科学研究的需要,各类疾病动物模型被广泛用来研究人类疾病的发生发展机制、药物筛选以及治疗评价等.本文全面梳理了我国疾病动物模型的研究和发展现状,分析了我国在这方面的特色优势以及与国际上的差距,内容涵盖了肿瘤、神经及精神疾病、感染及免疫性疾病、心血管与代谢性疾病、药物筛选等不同领域.简要介绍了国家自然科学基金对疾病动物模型项目的资助情况,同时指出了我国疾病模型今后的主要发展方向.

Research Status and Perspective of Disease Animal Models in China

With the increasing demand of medical research, disease animal models are widely used to study the mechanism of human disease initiation and development, drug screening, and treatment evaluation. The development of different kinds of disease animal models is reviewed. The advantages of China and the gap between China and the world in this field are analyzed. This review covers the fields of cancer, neurological diseases and mental health, infectious and immune diseases, cardiovascular and metabolic diseases, and drug screening. The main future directions in this field are pointed out and the funding related to ＇disease animal models＇ by the National Natural Science Foundation of China is introduced briefly.