华恢1号稻谷的大鼠慢性毒性试验研究

为了解长期喂养接触华恢1号稻谷是否会导致慢性毒性作用,尤其是进行性或不可逆的毒性作用以及致癌作用,本研究以SD大鼠为实验动物,进行了为期106周的慢性毒性试验.与普通稻谷对照组和基础饲料对照组比较,喂饲华恢1号稻谷106周的低、中、高剂量组SD大鼠,在一般临床症状、体重和食物利用率、血液学和血液生物化学指标、脏器重量和脏器系数、大体解剖学和病理组织学检查等各项观察指标上,均未见统计学意义和毒理学意义的差异.各组间,老年大鼠的肿瘤发生率为8.3%~10%,没有剂量反应关系,其发生部位主要在皮下,符合美国NIH Rodent 1980 catalogur SD大鼠乳腺肿瘤自然发病的正常范围.故认为华恢1号稻谷对SD大鼠没有明显的慢性毒性和致癌性.

Chronic Toxicity of Huahui No. 1 Rice Toward Rats

This paper aims to understand the chronic toxicity and carcinogencity of Huahui No. 1 rice, especially the progressive or unreversal toxicity and carcinogencity. Sprague-Dawley （SD） rats were selected in the 106-week chronic toxicity test. Compared with rats of non-gene modified rice group and basic feed group, no statistical difference and toxicological changes in clinical symptoms, body weight, food utilization efficiency, hematological and biochemical index, organ weight and index, gross anatomy and histopathological observation were found in rats fed low, medium and high dosages of Huahui No. 1 rice. Tumor incidences of old rats in different groups were between 8.3% and 10% and mostly observed in subcutaneous site, and no dose-response relationship was observed. The results were in accordance with the spontaneous tumor incidence by NIH Rodent 1980 catalogur SD rats. In conclusion, no chronic toxicity and carcinogencity were found in SD rats after they were fed with Huahui No. 1 rice for 106 weeks in the experiment.