Antimutagenicity of a suberin extract from Quercus suber cork |
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Authors: | Lívia Kri
kov Marta H Lopes Jozef Polnyi Anna Belicov Jozef Dobias Libor Ebringer |
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Institution: | a Institute of Cell Biology, Faculty of Science, Comenius University, Odborárske nám. 5, 81107 Bratislava, Slovak Republic;b Department of Chemistry, University of Aveiro, 3810 Aveiro, Portugal |
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Abstract: | The possible protective effect of a suberin extract from Quercus suber cork on acridine orange (AO)-, ofloxacin- and UV radiation-induced mutagenicity (bleaching activity) in Euglena gracilis was examined. To our knowledge, the present results are the first attempt to analyse suberin in relation to mutagenicity of some chemicals. Suberin exhibits a significant dose-dependent protective effect against AO-induced mutagenicity and the concentration of 500 μg/ml completely eliminates the Euglena-bleaching activity of AO. The mutagenicity of ofloxacin is also significantly reduced in the presence of suberin (125, 250 and 500 μg/ml). However, the moderate protective effect of suberin on UV radiation-induced mutagenicity was observed only at concentrations 500 and 1000 μg/ml. Our data shows that suberin extract from Q. suber cork possess antimutagenic properties and can be included in the group of natural antimutagens acting in a desmutagenic manner. |
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Keywords: | Euglena gracilis Suberin Acridine orange Ofloxacin Antimutagenicity |
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