2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges |
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Authors: | Kobori Akio Murase Takashi Suda Hitoshi Saito Isao Nakatani Kazuhiko |
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Institution: | PRESTO, Japan Science and Technology Agency, Kyoto 615-8510, Japan. |
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Abstract: | We have demonstrated that aromatic heterocycles having hydrogen-bonding surfaces complementary to those of nucleotide bases are effective molecular elements for the binding to single nucleotide bulges and base mismatches. We here report that a new molecule, 2-ureidoquinoline having an alignment of hydrogen-bonding groups in the order of acceptor-donor-donor stabilizes single cytosine and thymine bulges in duplex DNAs. Furthermore, a dimeric form of 2-ureidoquinoline stabilizes cytosine-cytosine and cytosine-thymine mismatches. |
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