|
|||||
|
|
Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality |
|
| Authors: | David Brühlmann Michael Sokolov Alessandro Butté Markus Sauer Jürgen Hemberger Jonathan Souquet Hervé Broly Martin Jordan |
| Institution: | 1. Merck Biopharma, Biotech Process Sciences, Merck Biopharma, Route de Fenil 25, 1804, Corsier‐sur‐Vevey, Switzerland;2. Department of Biotechnology and Biophysics, Biozentrum, Julius‐Maximilians‐Universit?t Würzburg, Germany;3. Department of Chemistry and Applied Biosciences, Institute of Chemical and Bioengineering, ETH Zürich, Switzerland;4. Institute for Biochemical Engineering and Analytics, University of Applied Sciences Giessen, Germany;5. +41 58 432 25 64+41 58 432 2013 |
| Abstract: | |
| Keywords: | CHO cell culture high‐throughput DoE antibody glycosylation multivariate analysis sequential process development |