Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN) |
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| Authors: | Shang Luqing Wang Qiang Fang Hao Mu Jiajia Wang Xuejian Yuan Yumei Wang Binghe Xu Wenfang |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, PR China. |
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| Abstract: | Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC(50) value 15.5+/-1.2microM. |
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