Developmental study of rat brain glutathione peroxidase and glutathione reductase |
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Authors: | Timothy S Brannan Howard S Maker Cipora Weiss |
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Institution: | (1) Department of Neurology, Mount Sinai School of Medicine, 10029 New York, New York;(2) Department of Neurology, The Bronx Veterans Administration Hospital, 0461 Bronx, New York |
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Abstract: | Glutathione peroxidase and glutathione reductase activities were measured in whole rat brains at selected ages from birth to adulthood. On a wet weight basis glutathione peroxidase activity increased 70% during development and glutathione reductase activity increased 160%. On a protein basis glutathione peroxidase declined slightly in activity during the first two weeks of life and then maintained the 14-day activity into adulthood while glutathione reductase showed a 30% increase in activity. While less than the developmental changes in many enzymes involved in aerobic glycolysis or catecholamine metabolism, these increases do suggest a role in CNS metabolism. |
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