Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids |
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Authors: | Wilkins Bryan J Daggett Kelly A Cropp T Ashton |
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Institution: | Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. |
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Abstract: | When isotopically labelled photo-crosslinking amino acids are site-specifically incorporated into proteins, in combination with the corresponding non-labeled analogue, cross-linked tryptic peptides are easily identified in mass spectra via characteristic "doublet" patterns. |
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