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Defective synthesis and release of astrocytic thrombospondin‐1 mediates the neuronal TDP‐43 proteinopathy,resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies
Authors:Arumugam Radhakrishnan Jayakumar  Xiao Y. Tong  Nagarajarao Shamaladevi  Stephanie Barcelona  Gabriel Gaidosh  Apeksha Agarwal  Michael D. Norenberg
Affiliation:1. Laboratory of Neuropathology, Veterans Affairs Medical Center, Miami, Florida, USA;2. Departments of Pathology, University of Miami School of Medicine, Miami, Florida, USA;3. Urology, University of Miami School of Medicine, Miami, Florida, USA;4. Ophthalmology, University of Miami School of Medicine, Miami, Florida, USA;5. Biochemistry & Molecular Biology, University of Miami School of Medicine, Miami, Florida, USA;6. Neurology, University of Miami School of Medicine, Miami, Florida, USA
Abstract:
Keywords:astrocytes  chronic traumatic encephalopathy  neurons  p‐tau  TDP‐43 proteinopathy  thrombospondin‐1
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