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Trafficking of adeno‐associated virus vectors across a model of the blood–brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells
Authors:Steven F. Merkel  Allison M. Andrews  Evan M. Lutton  Dakai Mu  Eloise Hudry  Bradley T. Hyman  Casey A. Maguire  Servio H. Ramirez
Affiliation:1. Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA;2. Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA;3. Department of Neurology, The Massachusetts General Hospital, Charlestown, Massachusetts, USA;4. NeuroDiscovery Center, Harvard Medical School, Boston, Massachusetts, USA;5. Alzheimer Research Unit, The Massachusetts General Hospital Institute for Neurodegenerative Disease, Charlestown, Massachusetts, USA;6. Shriners Hospitals Pediatric Research Center, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
Abstract:
Keywords:adeno‐associated virus  blood–  brain barrier  gene therapy  neurological disorders
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