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YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity
Authors:Guaragnella Nicoletta  Pereira Clara  Sousa Maria João  Antonacci Lucia  Passarella Salvatore  Côrte-Real Manuela  Marra Ersilia  Giannattasio Sergio
Institution:CNR, Istituto di Biomembrane e Bioenergetica, I-70126 Bari, Italy.
Abstract:Yeast cells lacking the metacaspase-encoding gene YCA1 (Δyca1) were compared with wild-type (WT) cells with respect to the occurrence, nature and time course of acetic-acid triggered death. We show that Δyca1 cells undergo programmed cell death (PCD) with a rate lower than that of the WT and that PCD in WT cells is caused at least in part by the caspase activity of Yca1p. Since in Δyca1 cells this effect is lost, but z-VAD-fmk does not prevent both WT and Δyca1 cell death, PCD in WT cells occurs via a Yca1p caspase and a non-caspase route with similar characteristics.
Keywords:Saccharomyces cerevisiae  PCD  Acetic acid  YCA1  Caspase  z-VAD-fmk
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