Simple and stereospecific homologation of urethane-protected alpha-amino acids to their higher homologs using HBTU. |
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| Authors: | G-R Vasanthakumar V V S Babu |
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| Affiliation: | Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr B.R. Ambedkar Veedhi, Bangalore 560 001, Karnataka, India. |
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| Abstract: | A simple, efficient and stereospecific approach for the homologation of urethane-protected alpha-amino acids to beta-amino acids by the Arndt-Eistert method employing Fmoc-/Boc-alpha-amino acid and 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate mixture for the acylation of diazomethane synthesizing the key intermediates Fmoc-/Boc-alpha-aminodiazomethanes as crystalline solids is described. |
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