首页 | 本学科首页   官方微博 | 高级检索  
     


Simple and stereospecific homologation of urethane-protected alpha-amino acids to their higher homologs using HBTU.
Authors:G-R Vasanthakumar  V V S Babu
Affiliation:Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr B.R. Ambedkar Veedhi, Bangalore 560 001, Karnataka, India.
Abstract:A simple, efficient and stereospecific approach for the homologation of urethane-protected alpha-amino acids to beta-amino acids by the Arndt-Eistert method employing Fmoc-/Boc-alpha-amino acid and 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate mixture for the acylation of diazomethane synthesizing the key intermediates Fmoc-/Boc-alpha-aminodiazomethanes as crystalline solids is described.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号