|
|||||
|
|
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors |
|
| Authors: | Parker Michael F Barten Donna M Bergstrom Carl P Bronson Joanne J Corsa Jason A Deshpande Milind S Felsenstein Kevin M Guss Valerie L Hansel Steven B Johnson Graham Keavy Daniel J Lau Wai Y Mock Jeremy Prasad C V C Polson Craig T Sloan Charles P Smith David W Wallace Owen B Wang Henry H Williams Andrew Zheng Ming |
| Affiliation: | Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com |
| Abstract: | A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |