Sublethal concentration of H<Subscript>2</Subscript>O<Subscript>2</Subscript> enhances the protective effect of mesenchymal stem cells in rat model of spinal cord injury期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Sublethal concentration of H2O2 enhances the protective effect of mesenchymal stem cells in rat model of spinal cord injury

Authors:	Asrin Rahimi Iraj Amiri Amaneh Mohammadi Roushandeh Zoleikha Golipour Choshali Zohreh Alizadeh Tayebeh Artimani Saeid Afshar Sara Soleimani Asl

Affiliation:	1.Endometrium and Endometriosis Research Center,Hamadan University of Medical Sciences,Hamadan,Iran;2.Anatomy Department, School of Medicine,Hamadan University of Medical Sciences,Hamadan,Iran;3.Research Center for Molecular Medicine,Hamadan University of Medical Sciences,Hamadan,Iran

Abstract:	Objective To investigate the effect of H₂O₂ on the migration and antioxidant defense of mesenchymal stem cells (MSCs) and the neurotrophic effects of H₂O₂-treated MSCs on spinal cord injury (SCI). Results Sublethal concentrations of H₂O₂ decreased cell migration and expression of CXCR4 and CCR2 as well as Nrf2 expression in MSCs. In the second phase, transplantation of treated and untreated MSCs to SCI caused minor changes in locomotor dysfunction. There was a significantly difference between cell-treated and spinal cord injury groups in expression of BDNF (brain-derived neurotrophic factor). Transplantation of H₂O₂-treated cells caused an increase in BDNF expression compared to non-treated cells. Conclusion Transplantation of H₂O₂-treated stem cells may have protective effects against SCI through by increasing neurotrophic factors.

Keywords:
本文献已被 SpringerLink 等数据库收录！

Objective

Results

Conclusion