Neuroanatomical localization of substance p: implications for central cardiovascular control |
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Authors: | C J Helke |
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Affiliation: | Department of Pharmacology, Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814 USA |
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Abstract: | The presence of substance P (SP) neurons in pathways known to be involved in the central control of the cardiovascular system has been studied with neuroanatomical and neurochemical techniques. SP-immunoreactive (SP-I) neurons are found in afferent baro- and chemoreceptor pathways which transmit information from peripheral receptors to the nucleus tractus solitarius. In addition, SP-I neurons located in the nucleus interfascicularis hypoglossi of the ventral medulla innervate the intermediolateral cell column, the site of origin of preganglionic sympthetic nerves. The role of these SP-I neurons in cardiovascular control remains to be determined. |
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Keywords: | Substance P Viscerosensory afferents Nucleus tractus solitarius Ventral medulla Intermediolateral cell column |
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