L-aspartate ammonia-lyase and fumarate hydratase share extensive sequence homology |
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| Authors: | J S Takagi M Tokushige Y Shimura M Kanehisa |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Kyoto University, Kyoto 606, Japan;2. Department of Biophysics, Faculty of Science, Kyoto University, Kyoto 606, Japan;3. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611, Japan;1. Unit-III, department of surgical oncology, Chittaranjan national cancer institute, 37, S.P. Mukherjee Road, 700026 Kolkata, West Bengal, India;2. Baraniya cooperative society, Flat No. F2, AL/1/C/14, action area 1A, street no. 22, Newrown, 700156 Kolkata, West Bengal, India;3. Department of oral medicine and radiology, Sri Hasanamba dental college and hospital, Vidyanagar, 573202 Hassan, Karnataka, India;1. Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, China;2. Department of Neurology, Children’s Hospital of Fudan University, Shanghai, China;3. Institute of Neurology, Fudan University, Shanghai, China;4. Department of Neurology, Jing''an District Centre Hospital of Shanghai, China;1. Division of Epidemiology, UC Berkeley School of Public Health, Berkeley, CA;2. Stanford University School of Medicine, Stanford, CA;3. Johns Hopkins Bloomberg School of Public Health, Department of Population, Family and Reproductive Health, Baltimore, MD;4. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY;5. Department of Obstetrics & Gynecology, Reproductive Sciences, University of California, San Francisco, San Francisco;6. Program in Public Health, University of California Irvine, Irvine;7. Division of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center, Stanford University School of Medicine, Stanford, CA;8. Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA;1. Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud, 150, Urca 22290-180, Rio de Janeiro, RJ, Brazil;2. Departamento de Ciências Naturais, Universidade Federal de São João Del Rei, 36301-000, São João Del Rei, MG, Brazil;3. Department of Physics, The Ohio State University, Columbus, OH 43210, USA |
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| Abstract: | Based on our recent determinations of the nucleotide sequences of the L-aspartate ammonia-lyase genes from Escherichia coli and Pseudomonas fluorescens, primary structures of the two L-aspartate ammonia-lyases and fumarate hydratases from Bacillus subtilis and E. coli (N-terminal partial sequence) were compared by computer analysis. These four enzymes exhibited a significant homology of at least 37%, implying that L-aspartate ammonia-lyase and fumarate hydratase share a common evolutionary origin. To authors' knowledge, this feature appears to be the first example showing that two kinds of enzymes catalyzing different types of reactions, albeit similar, share such a high degree of sequence homology. |
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