Characterization of a fibroblast cell from the urinary bladder wall |
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Authors: | Douglas E Coplen Pamela S Howard John W Duckett Howard M Snyder Edward J Macarak |
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Institution: | (1) Department of Histology, School of Dental Medicine, 4001 Spruce Street, 19104 Philadelphia, PA;(2) Children’s Hospital of Philadelphia and The Connective Tissue Research Institute, Philadelphia, PA |
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Abstract: | Summary For the first time we report on the growth, culture, and matrix production characteristics of a cell type isolated from the
lamina propria of the urinary bladder wall. A fibroblastlike cell was identified as distinct from bladder detrusor smooth
muscle cells and urothelium based on morphology, growth characteristics, and immunohistochemical staining. Characterization
of extracellular matrix synthesis by this cell type using35S-methionine metabolic labeling demonstrated that these cells are capable of secreting components of the surrounding connective
tissue, including several fibrillar collagens, a basement membrane collagen, and fibronectin. |
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Keywords: | bladder fibroblasts extracellular matrix |
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