Putting the brakes on cytokinesis with alpha-actinin |
| |
Authors: | Reichl Elizabeth M Robinson Douglas N |
| |
Affiliation: | Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. |
| |
Abstract: | Although signal transduction pathways provide spatiotemporal control of cytokinesis, additional regulation likely occurs through complex cytoskeletal network interactions. In this issue of Developmental Cell, Mukhina et al. (2007) show that myosin-II modulates the cortical lifetime of the actin crosslinker alpha-actinin, which in turn tunes actin filament dynamics, thereby controlling furrow ingression. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|