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Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus) |
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| Authors: | Melissa W Bennett Edward JDick Jr Natalia E Schlabritz-Loutsevitch Juan C Lopez-Alvarenga Priscilla C Williams R Mark Sharp & Gene B Hubbard |
| Institution: | Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA; Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA; Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA |
| Abstract: | Background Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown. Methods Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths. Results Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths. Conclusions Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors. |
| Keywords: | cancer Endometrium mass non-human primate uterus |