|
|||||
|
|
The effect of oral contraceptives on rat platelet membrane glycoproteins |
|
| Authors: | Bina Toor Lilian McGregor John L. McGregor Serge Renaud Kenneth J. Clemetson |
| Affiliation: | 1. INSERM U63, 22, Doyen Lépine, F-63500 Bron France;2. Laboratoire d''Hémobiologie, Faculté de Médicine, UER Alexis Carrel, rue Guillaume Paradin, F-96008 Lyon France;3. Theodor Kocher Institute, University of Berne, CH-3000 Berne 9 Switzerland |
| Abstract: | Female rats were administered oral contraceptives and the levels of sialic acid on platelet membrane and granule glycoproteins were compared to controls using a sialic acid assay and a fluorescein-conjugated wheat germ agglutinin binding assay and also by measuring the binding of 125I-labelled wheat germ agglutinin to glycoprotein bands from platelets separated by polyacrylamide electrophoresis. The contraceptive-treated rats showed increased levels of glycoprotein sialylation which may partly explain the altered physiological function of the platelets. |
| Keywords: | Contraceptive Glycoprotein band Sialic acid band (Rat platelet) |
| 本文献已被 ScienceDirect 等数据库收录！ | |