Genetic Variability of Trypanosoma cruzi:Implications for the Pathogenesis of Chagas Disease |
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| Authors: | Macedo A M Pena S D |
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| Institution: | 1. Instituto de Inmunología, Genética y Metabolismo (INIGEM), CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina;2. Instituto de Virología, Centro de Investigación en Ciencias Veterinarias y Agronómicas (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA);1. Departamento de Parasitologia y Medicina Tropical, Carrera de Medicina, Facultad de Ciencias Medicas, Universidad Catolica de Santiago de Guayaquil, Avenida Carlos Julio Arsemena Km 1 ½, Guayaquil, Ecuador;2. Department of Parasitology, Kochi Medical School, Kochi University, Kochi, Japan;3. Leishmaniasis Project (SINDE-SIU #415-214), Facultad de Ciencias Medicas, Universidad Catolica de Santiago de Guayaquil, Guayaquil, Ecuador;4. Division of Immunology, Kitasato University School of Allied Health Sciences, Kanagawa, Japan;5. Department of Microbiology, Faculty of Life Sciences, Graduate School of Health Sciences, Kumamoto University, Japan;6. Division of Medical Zoology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Tochigi, Japan |
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| Abstract: | Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or even overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but genetic variation of both the host and parasite is likely to be important. Here, Andréa M. Macedo and Sérgio D.J. Pena review the evidence showing a role for the genetic constitution of T. cruzi in determining the clinical characteristics of Chagas disease, and propose a ;clonal-histotropic model' for the pathogenesis of this disease. |
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