| Twist及Akt2在甲状腺乳头状癌中的表达及意义 |
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| 引用本文： | 王士娜,马静,滕猛,宦大为,王翠芳. Twist及Akt2在甲状腺乳头状癌中的表达及意义[J]. 中国组织化学与细胞化学杂志, 2011, 20(1): 56-59. DOI: 10.3870/zgzzhx.2011.01.013 |
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| 作者姓名： | 王士娜 马静 滕猛 宦大为 王翠芳 |
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| 作者单位： | 1. 沈阳医学院奉天医院病理科
2. 沈阳市第四人民医院麻醉科,辽宁,110024 |
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| 摘 要： | 目的探讨Twist、Akt2在甲状腺乳头状癌中的表达和相互关系。方法应用免疫组化方法,对60例甲状腺乳头状癌、10例结节性甲状腺肿进行Twist、Akt2表达的研究。结果甲状腺乳头状癌Twist及Akt2阳性表达率分别为81.67%(49/60)及60.00%(36/60),结节性甲状腺肿Twist及Akt2阳性表达率分别为0.00%(0/10)及10.00%(1/10),前者与后者相比差异有统计学意义(P<0.05);Twist及Akt2在甲状腺乳头状癌中的表达水平与病人的年龄及原发肿瘤分期无关,但与有无淋巴结转移相关(P<0.05),且Akt2的表达在T3,4期肿瘤及T1,2期肿瘤相比也具有显著性(P<0.05);Twist及Akt2的表达呈正相关(r=0.492,P=0.000)。结论在大多数甲状腺乳头状癌的上皮细胞中都存在Twist及Akt2的过表达,其淋巴结转移的发生与Twist及Akt2过表达或功能的不正常可能有密切的关系;Twist与Akt2的表达呈正相关。
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| 关 键 词： | 甲状腺癌 甲状腺乳头状癌 Twist Akt2 EMT |
Expression of Twist and Akt2 in papillary thyroid carcinoma and its significance |
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| Wang Shina,Ma Jing,Teng Meng,Huan Dawei,Wang Cuifang. Expression of Twist and Akt2 in papillary thyroid carcinoma and its significance[J]. Chinese Journal of Histochemistry and Cytochemistry, 2011, 20(1): 56-59. DOI: 10.3870/zgzzhx.2011.01.013 |
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| Authors: | Wang Shina Ma Jing Teng Meng Huan Dawei Wang Cuifang |
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| Affiliation: | Wang Shina,Ma Jing1,Teng Meng,Huan Dawei,Wang Cuifang(Department of Pathology,Fengtian Hospital,Shenyang Medical College,1The 4th People's Hospital of Shenyang,Linaoning 110024,China) |
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| Abstract: | Objective To study the expression of Twist,Akt2 in papillary thyroid carcinoma(PTC)and their relationship with clinicopathological factors.Methods Twist and Akt2 were measured in papillary thyroid carcinoma(n=60) and nodular goiter(n=10)by immunohistochemical staining.Results In PTC,positive rates of Twist and Akt2 were 81.7%(49/60) and 60.0%(36/60);in nodular goiter,they were 0.0%(0/10)and 10.0%(1/10),respectively.There were stutistically significant differences.The positive expressions of Twist and Akt2 w... |
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| Keywords: | Papillary Carcinoma Papillary Thyroid Carcinoma Twist Akt2 EMT |
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