HLA Class I allele frequencies in the Lebanese population |
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| Authors: | Sara Khansa Rouba HoteitDina Shammaa Rabab Abdel KhalekHussein El Halas Layal GreigeFatmeh Abbas Rami A.R. Mahfouz |
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| Affiliation: | Department of Pathology & Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon |
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| Abstract: | The highly polymorphic Human Leukocyte Antigen system encompasses different loci that have been studied in transplantation as well as diseases and population associated research. This study is the first and largest of its kind to describe the distribution of HLA-A, -B and -C alleles in Lebanon. Respectively, 1994, 1309 and 1163 Lebanese individuals referred for HLA typing and possible bone marrow/kidney donation were tested for HLA-A, HLA-B and HLA-C alleles using the polymerase chain reaction/Sequence specific priming (PCR-SSP) method. Our data were compared to that of several populations with interesting and common findings shared with the Moroccan, Jordanian, Tunisian, Omani, Korean, Chinese, Japanese, Peruan, Bulgarian, Irish, Polish, Spanish, Swiss, American, African and Brazilian populations. The following data concerning the Lebanese population will help future investigators to study the relation of HLA-A, -B and -C alleles with common diseases in Lebanon and will add to the available international literature. This new data will serve as a major reference report in the region. |
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| Keywords: | HLA, Human leukocyte antigen PCR, Polymerase chain reaction SSP, Sequence specific priming MHC, Major histocompatibility complex HPV, Human papilloma virus HLA-CI, Human leukocyte antigen-class I HLA-CII, Human leukocyte antigen-class II HCMV, Human cytomegalovirus MS, Multiple sclerosis CTL, Cytotoxic T-lymphocyte BD, Behç et's disease HIV, Human immunodeficiency virus AIDS, Acquired immune deficiency syndrome DLBL, Diffuse large B-cell lymphoma HCV, Hepatitis C virus MICA-A, Major histocompatibility complex class I chain-related gene A PSC, Primary sclerosing cholangitis NPC, Nasopharyngeal carcinoma EBV, Epstein&ndash Barr virus KIR, Killer immunoglobulin-like receptors AMD, Age related macular degeneration NHL, Non-Hodgkin's lymphoma SNP, Single nucleotide polymorphism TNF, Tumor necrosis factor |
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