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Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding
Authors:Numan AL_Rayyan  Umesh D. WankhadeKorie Bush  Deborah J. Good
Affiliation:Department of Human Nutrition, Foods and Exercise, Virginia Tech University, Blacksburg, VA 24061, USA
Abstract:
Keywords:A, adenosine   ARE, AU-rich element   βgal, beta galactosidase   bHLH, basic helix-loop-helix   bp, base pair   C, cytosine   dATP, deoxy adenosine tri-phosphate   DNA, deoxyribonucleic acid   G, guanosine   kb, kilobase   KO, knockout   MC4R, melanocortin 4 receptor   μg, microgram   μl, microliter   mRNA, messenger ribonucleic acid   miRNA, micro ribonucleic acid   NCBI, National Center for Biotechnology Information   ng, nanogram   NHLH2, nescient helix-loop-helix 2 (human)   Nhlh2, nescient helix-loop-helix 2 (mouse)   nt, nucleotide   oligo, oligonucleotide   PC1/3, prohormone convertase 1/3   QPCR, quantitative polymerase chain reaction   rRNA, ribosomal ribonucleic acid   SDS, sodium dodecyl sulfate   SNP, single nucleotide polymorphism   SV-40, simian virus 40   T, thymidine   U, uridine   UTR, untranslated region   V, volts   WT, wild type
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