Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree |
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Authors: | Rory J. Todhunter Raluca Mateescu George Lust Nancy I. Burton-Wurster Nathan L. Dykes Stuart P. Bliss Alma J. Williams Margaret Vernier-Singer Elizabeth Corey Carlos Harjes Richard L. Quaas Zhiwu Zhang Robert O. Gilbert Dietrich Volkman George Casella Rongling Wu Gregory M. Acland |
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Affiliation: | (1) Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca New York, 14853, USA;(2) James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca New York, 14853, USA;(3) Department of Animal Breeding, College of Agriculture and Life Sciences, Cornell University, Ithaca New York, 14853, USA;(4) Department of Statistics, University of Florida, Gainesville, Florida 32611, USA |
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Abstract: | Canine hip dysplasia is a common developmental inherited trait characterized by hip laxity, subluxation or incongruity of the femoral head and acetabulum in affected hips. The inheritance pattern is complex and the mutations contributing to trait expression are unknown. In the study reported here, 240 microsatellite markers distributed in 38 autosomes and the X chromosome were genotyped on 152 dogs from three generations of a crossbred pedigree based on trait-free Greyhound and dysplastic Labrador Retriever founders. Interval mapping was undertaken to map the QTL underlying the quantitative dysplastic traits of maximum passive hip laxity (the distraction index), the dorsolateral subluxation score, and the Norberg angle. Permutation testing was used to derive the chromosome-wide level of significance at p < 0.05 for each QTL. Chromosomes 4, 9, 10, 11 (p < 0.01), 16, 20, 22, 25, 29 (p < 0.01), 30, 35, and 37 harbor putative QTL for one or more traits. Successful detection of QTL was due to the crossbreed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools. |
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