Cardiovascular effects of the essential oil of Mentha x villosa in DOCA-salt-hypertensive rats. |
| |
Authors: | S Lahlou R Ferreira Lima Carneiro-Le o and JH Leal-Cardoso |
| |
Institution: | aDepartamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Recife-PE, Brasil bDepartamento de Ciências Fisiológicas, Universidade Estadual do Ceará, Fortaleza-CE, Brasil |
| |
Abstract: | The present study investigated the effects of chronic treatment with deoxycorticosterone-acetate (DOCA)-salt on cardiovascular responses to intravenous (i.v.) injection of the essential oil of Mentha x villosa (EOMV) in conscious rats. In both DOCA-salt-hypertensive and uninephrectomized control, conscious rats, i.v. bolus injections of EOMV (1 to 20 mg/kg body wt.) decreased mean aortic pressure (MAP) and heart rate (HR) in a dose-dependent manner. Treatment with DOCA-salt significantly enhanced EOMV-induced decreases in MAP, without affecting bradycardia. Likewise, both maximal percent and absolute decreases in MAP elicited by i.v. injection of the ganglion blocker, hexamethonium (30 mg/kg body wt.), were significantly greater in DOCA-salt-hypertensive than in control rats. In DOCA-salt-hypertensive rats, i.v. pretreatment with hexamethonium (30 mg/kg body wt.) reduced the bradycardia elicited by EOMV (1 to 20 mg/kg body wt.) without affecting the enhancement of EOMV-induced hypotension. These results show that i.v. treatment with EOMV decreases blood pressure in conscious DOCA-salt-hypertensive rats dose-dependently, and that this action is enhanced when compared with uninephrectomized controls. This enhancement could be related mainly to an increase in EOMV-induced vascular smooth muscle relaxation, rather than to enhanced sympathetic nervous system activity in this hypertensive model. |
| |
Keywords: | Mentha x villosa Labiatae essential oil cardiovascular effects DOCA-salt-hypertension conscious rat |
本文献已被 ScienceDirect 等数据库收录! |
|