The critical roles of mitophagy in cerebral ischemia |
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| Authors: | Yan-Cheng Tang Hong-Xia Tian Tao Yi Hu-Biao Chen |
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| Affiliation: | 1. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China2. Medical Research Department, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China3. HKBU Institute of Research and Continuing Education, Shenzhen 518057, China |
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| Abstract: | Mitochondria play a key role in various cell processes including ATP production, Ca2+ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia. |
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| Keywords: | autophagy mitophagy mitochondria cerebral ischemia |
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