The role of galectin-4 in physiology and diseases |
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Authors: | Zhan-Qi Cao Xiu-Li Guo |
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Affiliation: | Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 50012, China |
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Abstract: | Galectin-4, a tandem repeat member of the β-galactoside- binding proteins, possesses two carbohydraterecognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes. |
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Keywords: | galectin-4 lipid raft crosslinker intestinal inflammation tumor progression |
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