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NMR assignment of the N-terminal region of human La free and in complex with RNA |
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| Authors: | Domenico Sanfelice Geoff Kelly Stephen Curry Maria R Conte |
| Institution: | (1) Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunt’s House, Guy’s Campus, London, SE1 1UL, UK;(2) Biomedical NMR Centre, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK;(3) Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London, SW7 2AZ, UK |
| Abstract: | 1H, 15N and 13C chemical shift assignments are presented for the N-terminal region of human La protein, in the apo and 5′-UUUU RNA-bound state. Secondary structure analysis shows conformational changes in the interdomain linker upon complex formation. |
| Keywords: | La autoantigen NMR resonance assignment RNA interaction |
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