The origin of the Adams-Schuster difference spectrum of oxyhemoglobin. |
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Authors: | F C Knowles M J McDonald Q H Gibson |
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Affiliation: | Department of Biochemistry, Molecular and Cell Biology Wing Hall, Cornell University, Ithaca, N.Y. 14853, USA |
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Abstract: | The characteristic difference spectrum reported by Adams and Schuster (Biochem. Biophys. Res. Commun. 1974, , 525) on the addition of inositol hexaphosphate to oxyhemoglobin is similar to the difference spectrum between (i) isolated α- and β-chains, (ii) α- and β-semihemoglobins, (iii) addition of inorganic phosphate to oxyhemoglobin, (v) change in temperature of a solution of oxyhemoglobin, (v) change in pH of carp carboxyhemoglobin and (vi) addition of inositol hexaphosphate to α-semihemoglobin. The spectrum may also be generated by differentiation of the spectra of oxyhemoglobin and carboxyhemoglobin, implying that the common feature of the results reported above is a shift in the position of the absorption bands. This shift may arise from several causes and so its interpretation is uncertain. |
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