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Chemical incorporation of 1-methyladenosine into oligonucleotides |
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| Authors: | Mikhailov Sergey N Rozenski Jef Efimtseva Ekaterina V Busson Roger Van Aerschot Arthur Herdewijn Piet |
| Affiliation: | Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. |
| Abstract: | The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides. |
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