|
|||||
|
|
Synthesis of ceramidated GLA-60 derivatives |
|
| Authors: | Nakamura Tsuyoshi Shiozaki Masao Kurakata Shin-ichi |
| Affiliation: | Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan. |
| Abstract: | Ceramidated GLA-60 derivatives 11 and 11' were synthesized from 1 via glycosidation of ceramide derivative 12 as a glycosyl acceptor with GLA-60 derivative 5 as a glycosyl donor, and successive conversion. Compound 11' showed only weak LPS-antagonistic activity without showing any LPS-agonistic activity. |
| Keywords: | Ceramidated GLA-60 derivatives Glycosidation Glycosphingolipids LPS-antagonist |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |