Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN) |
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| Authors: | Smith Alexandra H Blevins Jon S Bachlani Gulnaz N Yang Xiaofeng F Norgard Michael V |
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| Affiliation: | Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA. |
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| Abstract: | The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi. |
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