Binding to erythrocyte membrane glycoproteins and carbohydrate specificity of F41 fimbriae of enterotoxigenic Escherichia coli |
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| Authors: | Mats Lindahl Torkel Wadström |
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| Institution: | Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Biomedicum, Box 583, S-751 23 Uppsala, Sweden |
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| Abstract: | Abstract Haemagglutination of enterotoxigenic Escherichia coli (ETEC) possessing F41 fimbriae was found to be inhibited by N -acetylgalactosamine. Other monosaccharides, such as N -acetylglucosamine, galactose and fucose were also inhibitors, although less effective than N -acetylgalactosamine. Purified F41 fimbriae bound to glycoproteins of human erythrocytes and glycophorin was found to act as an erythrocyte receptor for F41. |
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| Keywords: | F41 fimbriae carbohydrate specificity erythrocyte receptor enterotoxigenic Escherichia coli bacterial haemagglutinin |
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