HLA gene and haplotype frequencies in Galicia (NW spain) |
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| Authors: | T A Varela R Lodeiro J Fariña |
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| Institution: | 1. Dept. de Biología Animal (Antropologia), Fac. de Biologia, Univ. de Santiago, Santiago de Compostela, Espa?a
2. Dept. de Biología Fundamental, Area de Genética, Fac. de Ciencias, Univ. de Vigo. Orense, Campus de Orense, Espa?a
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| Abstract: | The purpose of this paper is to present the genetic distribution at the HLA-A, B and C loci in the Galician population (Spain).
A random sample of 264 unrelated individuals from the autochtonous population were tested. The gene frequencies observed at
the three loci are within the respective variability ranges found in European populations. The linkage disequilibrium value,
D, was calculated using the phenotype frequencies at the A-B, A-C and B-C loci; the most frequent haplotype combinations were
A1-B8 and A2-B44, A2-Cw7 and A1-Cw7, and B7-Cw7 and B35-Cw4, respectively. |
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| Keywords: | HLA antigens Gene frequencies Haplotype frequencies Galicia/Spain |
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