|
|||||
|
|
The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations |
|
| Authors: | A T Natarajan F Darroudi L H F Mullenders and M Meijers |
| Affiliation: | a Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Wassenaarseweg 72, 2333, Al Leiden, The Netherlands b J.A. Cohen Institute, Interuniversity Institute of Radiopathology and Radiation Protection, Leiden, The Netherlands |
| Abstract: | Short treatment (up to 1 h) of cytosine arabinoside (araC) increases the frequencies of aberrations induced by X-rays in human lymphocytes, evaluated at the first mitosis following stimulation, or as prematurely condensed chromosomes of G0 nuclei. Parallel biochemical experiments using nucleoid sedimentation technique, demonstrate that araC inhibits rejoining of DNA-strand breaks effectively. These results point out that X-ray-induced short-lived DNA strand breaks lead to chromosomal aberrations in human lymphocytes. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |