Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected |
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Authors: | Jiang Yi Xia Xuanping Wang Wenxing Lin Limiao Xu Changlong Cai Zhenzai Zheng Bo Pei Jihua Shen Sujian Xia Bing |
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Institution: | (1) Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, People’s Republic of China;(2) Department of Gastroenterology, Wuhan University Zhongnan Hospital, Wuhan, 430071, People’s Republic of China |
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Abstract: | Increased levels of homocysteine are found systemically and in intestinal mucosa of patients with inflammatory bowel disease,
and, specifically, in ulcerative colitis (UC). However, there are controversial reports regarding the factors contributing
to increased levels of homocysteine in UC. Furthermore, little information is available regarding the relationship between
hyperhomocysteinemia (HHcy), vitamin status, and genetic polymorphisms of homocysteine-related enzymes in these patients.
This study examined four functional polymorphisms linked to homocysteine metabolism (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G), and evaluated plasma levels of homocysteine, folate, and vitamin B12 in 310 consecutive patients with UC and 936 age- and sex-matched healthy controls from southeast China. The variant allele
and genotypic frequencies in MTHFR A1298C, MTR A2756G and MTRR A66G genes were significantly higher in patients with UC compared to healthy controls. Further, HHcy and low levels of folate
and vitamin B12 were more frequent in patients with UC. The MTR 2756G allele, extent of the disease, and gender were the independent determinants of HHcy in these patients. These findings
suggest that genetic and nutritional factors have a synergetic effect on HHcy in patients with UC. In conclusion, our data
highlight a prevention strategy for moderation of HHcy and supplementation with folate and vitamine B12 in patients with UC from Southeast China. |
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