Molecular cloning and sequence analysis of cDNA coding for canine gastrin |
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| Authors: | S C Kang K L Agarwal O J Yoo |
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| Institution: | Department of Biological Science and Engineering, Korea Advanced Institute of Science and Technology, Seoul. |
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| Abstract: | We have isolated and sequenced cDNA clones encoding for preprogastrin from a canine antral cDNA library. Comparison of this sequence with those of porcine, human, and rat gastrin reveals extensive (83%) homology in the gastrin coding region as well as short regions of conserved nucleotides in the noncoding regions. The canine sequence encodes a preprogastrin of 104 amino acids which consists of a signal peptide, a 37-amino acid prosegment, and a 34-amino acid gastrin sequence, followed by a glycine (the amide donor), and flanked by pairs of arginine residues. |
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